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	Provedor de dados ArchiMer (1) Autor Avarre, Jean-christophe (1) Boulo, Viviane (1) De Lorgeril, Julien (1) Escoubas, Jean-michel (1) Montagnani, Caroline (1) Quiquand, M (1) Mais... Palavra-chave Crassostrea gigas (1) Damage associated molecular pattern (1) Metalloproteinase (1) Mollusk immunity (1) Oyster (1) Tissue inhibitor of metalloproteinase (1) Mais... Tipo do documento Text (1) Ano 2007 (1) País France (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última First evidence of the activation of Cg-timp, an immune response component of pacific oysters, through a damage-associated molecular pattern pathway ArchiMer Montagnani, Caroline; Avarre, Jean-christophe; De Lorgeril, Julien; Quiquand, M; Boulo, Viviane; Escoubas, Jean-michel. In a previous work, we characterized a Crassostrea gigas cPNA (Cg-timp) encoding a protein which presents all the features of vertebrate tissue inhibitor of metalloproteinase (TIMP). The expression pattern of this gene led us to propose that Cg-timp is an important factor in oyster wound heating and defense mechanisms. Here we describe the analysis of Cg-timp expression in oysters challenged by live or dead bacteria as well as by bacterial secretory/excretory products and metalloproteinase. Surprisingly, bacterial secretory/excretory products activate Cg-timp gene expression whereas heat-inactivated ones do not. To address the question of the signal transduction pathway involved in Cg-timp gene activation, we isolated and sequenced Cg-timp promoter and... Tipo: Text Palavras-chave: Damage associated molecular pattern; Tissue inhibitor of metalloproteinase; Metalloproteinase; Mollusk immunity; Crassostrea gigas; Oyster. Ano: 2007 URL: http://archimer.ifremer.fr/doc/2007/publication-2094.pdf Registros recuperados: 1 Primeira ... 1 ... Última

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